http://bugs.gentoo.org/260726

--- wine-1.1.15/configure
+++ wine-1.1.15/configure
@@ -3943,7 +3943,7 @@
 $as_echo "$wine_cv_toolsdir" >&6; }
 TOOLSDIR=$wine_cv_toolsdir
 
-if test -n "$host_alias"
+if test -n "$host_alias" -a "$host_alias" != "$build_alias"
 then
     TARGETFLAGS="-b $host_alias $TARGETFLAGS"